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Integrated genetic and metabolic landscapes predict vulnerabilities of temozolomide resistant glioblastoma cells
Metabolic reprogramming and its molecular underpinnings are critical to unravel the duality of cancer cell function and chemo-resistance. Here, we use a constraints-based integrated approach to delineate the interplay between metabolism and epigenetics, hardwired in the genome, to shape temozolomide...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794364/ https://www.ncbi.nlm.nih.gov/pubmed/33420045 http://dx.doi.org/10.1038/s41540-020-00161-7 |