Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally discovered as the product of an uncultivable plant endosymbiont, is synthesized by a complex biosynthetic system comprising two nonribosomal peptide synthetase (NRPS) assembly lines. Here we characterize a cultivabl...

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Detalles Bibliográficos
Autores principales: Hermes, Cornelia, Richarz, René, Wirtz, Daniel A., Patt, Julian, Hanke, Wiebke, Kehraus, Stefan, Voß, Jan Hendrik, Küppers, Jim, Ohbayashi, Tsubasa, Namasivayam, Vigneshwaran, Alenfelder, Judith, Inoue, Asuka, Mergaert, Peter, Gütschow, Michael, Müller, Christa E., Kostenis, Evi, König, Gabriele M., Crüsemann, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794379/
https://www.ncbi.nlm.nih.gov/pubmed/33420046
http://dx.doi.org/10.1038/s41467-020-20418-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794379/
https://www.ncbi.nlm.nih.gov/pubmed/33420046
http://dx.doi.org/10.1038/s41467-020-20418-3

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