Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and CARD8 use their C-terminal (CT) fragments containing a caspase...

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Detalles Bibliográficos
Autores principales: Robert Hollingsworth, L., David, Liron, Li, Yang, Griswold, Andrew R., Ruan, Jianbin, Sharif, Humayun, Fontana, Pietro, Orth-He, Elizabeth L., Fu, Tian-Min, Bachovchin, Daniel A., Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794386/
https://www.ncbi.nlm.nih.gov/pubmed/33420033
http://dx.doi.org/10.1038/s41467-020-20320-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794386/
https://www.ncbi.nlm.nih.gov/pubmed/33420033
http://dx.doi.org/10.1038/s41467-020-20320-y

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