Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models

Research on new cancer drugs is performed either through gene knockout studies or phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and time-consuming. Computational framework, e.g., genome-scale metabolic models (GSMMs), could be a good alternative to find pote...

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Detalles Bibliográficos
Autores principales: Paul, Abhijit, Anand, Rajat, Karmakar, Sonali Porey, Rawat, Surender, Bairagi, Nandadulal, Chatterjee, Samrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794450/
https://www.ncbi.nlm.nih.gov/pubmed/33420254
http://dx.doi.org/10.1038/s41598-020-80561-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794450/
https://www.ncbi.nlm.nih.gov/pubmed/33420254
http://dx.doi.org/10.1038/s41598-020-80561-1

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