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Exploring gene knockout strategies to identify potential drug targets using genome-scale metabolic models
Research on new cancer drugs is performed either through gene knockout studies or phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and time-consuming. Computational framework, e.g., genome-scale metabolic models (GSMMs), could be a good alternative to find pote...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794450/ https://www.ncbi.nlm.nih.gov/pubmed/33420254 http://dx.doi.org/10.1038/s41598-020-80561-1 |