An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

Cytochrome P450 (CYP) heme monooxygenases require two electrons for their catalytic cycle. For mammalian microsomal CYPs, key enzymes for xenobiotic metabolism and steroidogenesis and important drug targets and biocatalysts, the electrons are transferred by NADPH-cytochrome P450 oxidoreductase (CPR)...

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Detalles Bibliográficos
Autores principales: Mukherjee, Goutam, Nandekar, Prajwal P., Wade, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794467/
https://www.ncbi.nlm.nih.gov/pubmed/33420418
http://dx.doi.org/10.1038/s42003-020-01568-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794467/
https://www.ncbi.nlm.nih.gov/pubmed/33420418
http://dx.doi.org/10.1038/s42003-020-01568-y

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