Voltage-independent GluN2A-type NMDA receptor Ca(2+) signaling promotes audiogenic seizures, attentional and cognitive deficits in mice

The NMDA receptor-mediated Ca(2+) signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations of this coincidence detection provoked complex clinical phenotypes, rangin...

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Detalles Bibliográficos
Autores principales: Bertocchi, Ilaria, Eltokhi, Ahmed, Rozov, Andrey, Chi, Vivan Nguyễn, Jensen, Vidar, Bus, Thorsten, Pawlak, Verena, Serafino, Marta, Sonntag, Hannah, Yang, Boyi, Burnashev, Nail, Li, Shi-Bin, Obenhaus, Horst A., Both, Martin, Niewoehner, Burkhard, Single, Frank N., Briese, Michael, Boerner, Thomas, Gass, Peter, Rawlins, John Nick P., Köhr, Georg, Bannerman, David M., Sprengel, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794508/
https://www.ncbi.nlm.nih.gov/pubmed/33420383
http://dx.doi.org/10.1038/s42003-020-01538-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794508/
https://www.ncbi.nlm.nih.gov/pubmed/33420383
http://dx.doi.org/10.1038/s42003-020-01538-4

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