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Anti-HCMV activity by an irreversible p97 inhibitor LC-1310

The AAA+ (ATPase associated with various cellular activities) protein p97, also called valosin-containing protein, is a hexameric ring ATPase and uses ATP hydrolysis to unfold or extract proteins from biological complexes. Many cellular processes are affected by p97 including ER-associated degradati...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Soto-Acosta, Ruben, Ding, Rui, Chen, Liqiang, Geraghty, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794631/
https://www.ncbi.nlm.nih.gov/pubmed/33456290
http://dx.doi.org/10.1007/s00044-020-02679-1