Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations

Many heritable genetic disorders arise from nonsense mutations, which generate premature termination codons (PTCs) in transcribed mRNA. PTCs ablate protein synthesis by prematurely terminating the translation of mutant mRNA, as well as reducing mutant mRNA quantity through targeted degradation by no...

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Detalles Bibliográficos
Autores principales: McHugh, Daniel R., Cotton, Calvin U., Hodges, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794695/
https://www.ncbi.nlm.nih.gov/pubmed/33396210
http://dx.doi.org/10.3390/ijms22010344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794695/
https://www.ncbi.nlm.nih.gov/pubmed/33396210
http://dx.doi.org/10.3390/ijms22010344

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