Structure-Acid Lability Relationship of N-alkylated α,α-dialkylglycine Obtained via a Ugi Multicomponent Reaction

Using the classical Ugi four-component reaction to fuse an amine, ketone, carboxylic acid, and isocyanide, here we prepared a short library of N-alkylated α,α-dialkylglycine derivatives. Due to the polyfunctionality of the dipeptidic scaffold, this highly steric hindered system shows an interesting...

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Detalles Bibliográficos
Autores principales: Ramos-Tomillero, Iván, Sánchez, Marisa K., Rodríguez, Hortensia, Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794957/
https://www.ncbi.nlm.nih.gov/pubmed/33401754
http://dx.doi.org/10.3390/molecules26010197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794957/
https://www.ncbi.nlm.nih.gov/pubmed/33401754
http://dx.doi.org/10.3390/molecules26010197

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