Cargando…

ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation

SIMPLE SUMMARY: Prostate cancer is the most frequently diagnosed cancer in men. Despite the importance of radical radiotherapy for the management of this disease, recurrence remains a challenge. PTEN is a tumour suppressor that is frequently inactivated in advanced prostate cancer and has been assoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hanna, Conor, Dunne, Victoria L., Walker, Steven M., Butterworth, Karl T., McCabe, Nuala, Waugh, David J. J., Kennedy, Richard D., Prise, Kevin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794981/ https://www.ncbi.nlm.nih.gov/pubmed/33396656 http://dx.doi.org/10.3390/cancers13010079

Ejemplares similares

The role of PTEN as a cancer biomarker
por: McCabe, Nuala, et al.
Publicado: (2016)

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin
por: O'Flanagan, Ciara H., et al.
Publicado: (2016)

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation
por: Cowell, Ian G., et al.
Publicado: (2007)

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation
por: Giallourou, Natasa S., et al.
Publicado: (2018)

Cinnarizine and flunarizine as radiation sensitisers in two murine tumours.
por: Wood, P. J., et al.
Publicado: (1988)

Inhibition of lysis of sensitised tumour cells in the presence of complement.
por: Hartveit, F.
Publicado: (1965)

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy
por: Shapiro, Daniel D., et al.
Publicado: (2023)

Ionisation
Publicado: (1911)

Diversity of ATM gene variants: a population-based genome data analysis for precision medicine
por: Fukunaga, Hisanori, et al.
Publicado: (2019)

Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
por: Marini, Patrizia, et al.
Publicado: (2005)

Mesenchymal Stem Cell Expressing TRAIL as Targeted Therapy against Sensitised Tumour
por: Shaik Fakiruddin, Kamal, et al.
Publicado: (2018)

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)
por: Duverger, V, et al.
Publicado: (2004)

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
por: Gilmore, Elaine, et al.
Publicado: (2019)

Rayonnements ionisants
por: CERN. Geneva. Audiovisual Unit
Publicado: (1991)

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
por: Yamamoto, Kenta, et al.
Publicado: (2016)

Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease
por: Walker, Simon R., et al.
Publicado: (2021)

Impact of superparamagnetic iron oxide nanoparticles on in vitro and in vivo radiosensitisation of cancer cells
por: Russell, Emily, et al.
Publicado: (2021)

Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction
por: Lickliter, J D, et al.
Publicado: (2007)

Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells
por: Du, Li Qing, et al.
Publicado: (2013)

Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
por: Herbert, Katharine J., et al.
Publicado: (2020)

The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
por: Tuieng, Ren Jie, et al.
Publicado: (2021)

Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma
por: Armstrong, Chris W D, et al.
Publicado: (2020)

The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma
por: Stewart, Connor E., et al.
Publicado: (2022)

A Rare Paraspinal Desmoid Tumour following Instrumented Scoliosis Correction in an Adolescent
por: McCabe, Fergus J., et al.
Publicado: (2021)

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
por: Meijer, A, et al.
Publicado: (2013)

Arcana ; Intégrales ; Ionisation /
por: Varése, Edgard, 1883-1965
Publicado: (1995)

Ionisation cooling in FFAG's
por: Schönauer, Horst Otto
Publicado: (2001)

WHAT IS IONISING RADIATION?
por: Vanden Broeck, Renilde
Publicado: (2019)

Ionisation Cooling in FFAG's
por: Schönauer, H
Publicado: (2001)

Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa
por: de Bruijn, M T, et al.
Publicado: (2010)

Tumour cells are sensitised to ferroptosis via RB1CC1‐mediated transcriptional reprogramming
por: Xue, Xiangfei, et al.
Publicado: (2022)

HLA sensitisation: can it be prevented?
por: Rees, Lesley, et al.
Publicado: (2014)

Sensitisation patterns to tomato seed
por: González, Miguel, et al.
Publicado: (2015)

Additive interaction of gefitinib (‘Iressa’, ZD1839) and ionising radiation in human tumour cells in vitro
por: Giocanti, N, et al.
Publicado: (2004)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children
por: van der Valk, J. P. M., et al.
Publicado: (2017)

Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies.
por: Cuomo, V., et al.
Publicado: (1990)

The second module of the ionisation hodoscope
por: Ferro-Luzzi, Massimiliano, et al.
Publicado: (1997)

Ionising Radiation: Levels and Effects
por: Lajtha, L. G.
Publicado: (1973)

Plasmas et milieux ionisés
por: Schatzman, Evry L
Publicado: (1968)

The second module of the ionisation hodoscope
por: Detraz, C, et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_0uatnp73jn0l2977cs8p5s7hvj