New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models

Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer’s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where...

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Detalles Bibliográficos
Autores principales: Chai, Amanda B., Hartz, Anika M. S., Gao, Xuexin, Yang, Alryel, Callaghan, Richard, Gelissen, Ingrid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795149/
https://www.ncbi.nlm.nih.gov/pubmed/33383667
http://dx.doi.org/10.3390/ijms22010246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795149/
https://www.ncbi.nlm.nih.gov/pubmed/33383667
http://dx.doi.org/10.3390/ijms22010246

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