Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKI-Resistant Lung Cancer

SIMPLE SUMMARY: In this study, we employed CRISPR/Cas9 editing technology to introduce the EGFR C797S mutation into an NSCLC cell line harboring EGFR L858R/T790M to establish a cellular model for the investigation of the resistance mechanism associated with the acquired C797S mutation and to explore...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Tong-Hong, Wu, Chih-Ching, Huang, Kuo-Yen, Leu, Yann-Lii, Yang, Shuenn-Chen, Chen, Ci-Ling, Chen, Chi-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795510/
https://www.ncbi.nlm.nih.gov/pubmed/33396393
http://dx.doi.org/10.3390/cancers13010111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795510/
https://www.ncbi.nlm.nih.gov/pubmed/33396393
http://dx.doi.org/10.3390/cancers13010111

Ejemplares similares