Acriflavine, a Potent Inhibitor of HIF-1α, Disturbs Glucose Metabolism and Suppresses ATF4-Protective Pathways in Melanoma under Non-hypoxic Conditions

SIMPLE SUMMARY: Hypoxia is a common feature in solid tumors such as melanoma, contributing locally and systemically to tumor progression. Although the hypoxia response in tumor cells is well understood, the role of constitutively activated hypoxia-inducible factor (HIF)-1α in normoxic conditions is...

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Detalles Bibliográficos
Autores principales: Martí-Díaz, Román, Montenegro, María F., Cabezas-Herrera, Juan, Goding, Colin R., Rodríguez-López, José Neptuno, Sánchez-del-Campo, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795823/
https://www.ncbi.nlm.nih.gov/pubmed/33396270
http://dx.doi.org/10.3390/cancers13010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795823/
https://www.ncbi.nlm.nih.gov/pubmed/33396270
http://dx.doi.org/10.3390/cancers13010102

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