Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity

Pancreatic β-cell-specific clock knockout mice develop β-cell oxidative-stress and failure, as well as glucose-intolerance. How inflammatory stress affects the cellular clock is under-investigated. Real-time recording of Per2:luciferase reporter activity in murine and human pancreatic islets demonst...

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Detalles Bibliográficos
Autores principales: Andersen, Phillip Alexander Keller, Petrenko, Volodymyr, Rose, Peter Horskjær, Koomen, Melissa, Fischer, Nico, Ghiasi, Seyed Mojtaba, Dahlby, Tina, Dibner, Charna, Mandrup-Poulsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795908/
https://www.ncbi.nlm.nih.gov/pubmed/33374803
http://dx.doi.org/10.3390/ijms22010083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795908/
https://www.ncbi.nlm.nih.gov/pubmed/33374803
http://dx.doi.org/10.3390/ijms22010083

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