Studying the Binding Modes of Novel 2-Aminopyridine Derivatives as Effective and Selective c-Met Kinase Type 1 Inhibitors Using Molecular Modeling Approaches

The mesenchymal epithelial cell transforming factor c-Met, encoded by c-Met proto-oncogene and known as a high-affinity receptor for Hepatocyte Growth Factor (HGF), is one of the receptor tyrosine kinases (RTKs) members. The HGF/c-Met signaling pathway has close correlation with tumor growth, invasi...

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Detalles Bibliográficos
Autores principales: Ye, Qianwen, Fu, Chenggong, Li, Jiazhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795969/
https://www.ncbi.nlm.nih.gov/pubmed/33374386
http://dx.doi.org/10.3390/molecules26010052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795969/
https://www.ncbi.nlm.nih.gov/pubmed/33374386
http://dx.doi.org/10.3390/molecules26010052

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