The Relative Role of Toxins A and B in the Virulence of Clotridioides difficile

Most pathogenic strains of C. difficile possess two large molecular weight single unit toxins with four similar functional domains. The toxins disrupt the actin cytoskeleton of intestinal epithelial cells leading to loss of tight junctions, which ultimately manifests as diarrhea in the host. While i...

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Detalles Bibliográficos
Autores principales: Skinner, Andrew M., Phillips, S. Tyler, Merrigan, Michelle M., O’Leary, Kevin J., Sambol, Susan P., Siddiqui, Farida, Peterson, Lance R., Gerding, Dale N., Johnson, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796042/
https://www.ncbi.nlm.nih.gov/pubmed/33396595
http://dx.doi.org/10.3390/jcm10010096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796042/
https://www.ncbi.nlm.nih.gov/pubmed/33396595
http://dx.doi.org/10.3390/jcm10010096

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