Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study pro...

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Detalles Bibliográficos
Autores principales: Avram, Vlad F., Chamkha, Imen, Åsander-Frostner, Eleonor, Ehinger, Johannes K., Timar, Romulus Z., Hansson, Magnus J., Muntean, Danina M., Elmér, Eskil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796258/
https://www.ncbi.nlm.nih.gov/pubmed/33401621
http://dx.doi.org/10.3390/ijms22010424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796258/
https://www.ncbi.nlm.nih.gov/pubmed/33401621
http://dx.doi.org/10.3390/ijms22010424

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