SATB1-Mediated Upregulation of the Oncogenic Receptor Tyrosine Kinase HER3 Antagonizes MET Inhibition in Gastric Cancer Cells

MET-amplified gastric cancer cells are extremely sensitive to MET inhibition in vitro, whereas clinical efficacy of MET inhibitors is disappointing. The compensatory activation of other oncogenic growth factor receptors may serve as an underlying mechanism of resistance. In this study, we analyzed t...

Descripción completa

Detalles Bibliográficos
Autores principales: Jenke, Robert, Holzhäuser-Rein, Miriam, Mueller-Wilke, Stefanie, Lordick, Florian, Aigner, Achim, Büch, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796274/
https://www.ncbi.nlm.nih.gov/pubmed/33374770
http://dx.doi.org/10.3390/ijms22010082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796274/
https://www.ncbi.nlm.nih.gov/pubmed/33374770
http://dx.doi.org/10.3390/ijms22010082

Ejemplares similares