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Improved Synthesis of Phosphoramidite-Protected N(6)-Methyladenosine via BOP-Mediated S(N)Ar Reaction
N(6)-methyladenosine(m(6)A) is the most abundant modification in mRNA. Studies on proteins that introduce and bind m(6)A require the efficient synthesis of oligonucleotides containing m(6)A. We report an improved five-step synthesis of the m(6)A phosphoramidite starting from inosine, utilising a 1-H...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796277/ https://www.ncbi.nlm.nih.gov/pubmed/33396208 http://dx.doi.org/10.3390/molecules26010147 |