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Improved Synthesis of Phosphoramidite-Protected N(6)-Methyladenosine via BOP-Mediated S(N)Ar Reaction

N(6)-methyladenosine(m(6)A) is the most abundant modification in mRNA. Studies on proteins that introduce and bind m(6)A require the efficient synthesis of oligonucleotides containing m(6)A. We report an improved five-step synthesis of the m(6)A phosphoramidite starting from inosine, utilising a 1-H...

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Detalles Bibliográficos
Autores principales:	Shishodia, Shifali, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796277/ https://www.ncbi.nlm.nih.gov/pubmed/33396208 http://dx.doi.org/10.3390/molecules26010147

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