Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells

SIMPLE SUMMARY: Effective treatment of cancer is often limited by the resistance of cancer cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) relies on the efflux of toxic drugs from cancer cells, mediated by P-glycoprotein (Pgp). Circumventing Pgp-mediated resis...

Descripción completa

Detalles Bibliográficos
Autores principales: Pape, Veronika F.S., Gaál, Anikó, Szatmári, István, Kucsma, Nóra, Szoboszlai, Norbert, Streli, Christina, Fülöp, Ferenc, Enyedy, Éva A., Szakács, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796460/
https://www.ncbi.nlm.nih.gov/pubmed/33466433
http://dx.doi.org/10.3390/cancers13010154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796460/
https://www.ncbi.nlm.nih.gov/pubmed/33466433
http://dx.doi.org/10.3390/cancers13010154

Ejemplares similares