Cargando…

Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells

SIMPLE SUMMARY: Effective treatment of cancer is often limited by the resistance of cancer cells to chemotherapy. A well-described mechanism supporting multidrug resistance (MDR) relies on the efflux of toxic drugs from cancer cells, mediated by P-glycoprotein (Pgp). Circumventing Pgp-mediated resis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pape, Veronika F.S., Gaál, Anikó, Szatmári, István, Kucsma, Nóra, Szoboszlai, Norbert, Streli, Christina, Fülöp, Ferenc, Enyedy, Éva A., Szakács, Gergely
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796460/ https://www.ncbi.nlm.nih.gov/pubmed/33466433 http://dx.doi.org/10.3390/cancers13010154

Ejemplares similares

Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer
por: Pape, Veronika F. S., et al.
Publicado: (2022)

Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction
por: Csuvik, Oszkár, et al.
Publicado: (2023)

Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells
por: Pivarcsik, Tamás, et al.
Publicado: (2022)

Mannich base-connected syntheses mediated by ortho-quinone methides
por: Barta, Petra, et al.
Publicado: (2018)

Synthetic- and DFT modelling studies on regioselective modified Mannich reactions of hydroxy-KYNA derivatives
por: Lőrinczi, Bálint, et al.
Publicado: (2020)

8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules †
por: Pivarcsik, Tamás, et al.
Publicado: (2021)

Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation
por: Gaál, Anikó, et al.
Publicado: (2020)

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents †
por: Csuvik, Oszkár, et al.
Publicado: (2022)

KYNA Derivatives with Modified Skeleton; Hydroxyquinolines with Potential Neuroprotective Effect †
por: Lőrinczi, Bálint, et al.
Publicado: (2021)

Measuring peroxidasin activity in live cells using bromide addition for signal amplification
por: Pape, Veronika F.S., et al.
Publicado: (2022)

The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification
por: Rakvács, Zsófia, et al.
Publicado: (2019)

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions
por: Szabó, Edit, et al.
Publicado: (2018)

Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
por: Lőrinczi, Bálint, et al.
Publicado: (2022)

Solution speciation and human serum protein binding of indium(III) complexes of 8-hydroxyquinoline, deferiprone and maltol
por: Dömötör, Orsolya, et al.
Publicado: (2022)

Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway
por: Marton, Lívia, et al.
Publicado: (2018)

Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives
por: Lőrincz, Eszter Boglárka, et al.
Publicado: (2023)

Solvent-Free C-3 Coupling of Azaindoles with Cyclic Imines
por: Belasri, Khadija, et al.
Publicado: (2019)

Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes
por: Ribeiro, Nádia, et al.
Publicado: (2023)

Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein
por: Kiss, Katalin, et al.
Publicado: (2015)

The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis
por: Szebeni, Gábor J., et al.
Publicado: (2019)

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives
por: Lőrinczi, Bálint, et al.
Publicado: (2020)

Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands
por: Pivarcsik, Tamás, et al.
Publicado: (2021)

Establishment and Characterization of a Brca1(−/−), p53(−/−) Mouse Mammary Tumor Cell Line
por: Hámori, Lilla, et al.
Publicado: (2020)

The Redox-Mannich Reaction
por: Chen, Weijie, et al.
Publicado: (2014)

Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole
por: Ribeiro, Nádia, et al.
Publicado: (2022)

Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential
por: Côrte-Real, Leonor, et al.
Publicado: (2023)

Formation and Entrapment of Tris(8-hydroxyquinoline)aluminum from 8-Hydroxyquinoline in Anodic Porous Alumina
por: Yamaguchi, Shohei, et al.
Publicado: (2016)

Identifying new topoisomerase II poison scaffolds by combining publicly available toxicity data and 2D/3D-based virtual screening
por: Lovrics, Anna, et al.
Publicado: (2019)

Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae
por: Lawung, Ratana, et al.
Publicado: (2018)

Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1
por: Patik, Izabel, et al.
Publicado: (2018)

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen
por: Windt, Tímea, et al.
Publicado: (2019)

Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells
por: Tátrai, Enikő, et al.
Publicado: (2017)

Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction
por: Funk, Petr, et al.
Publicado: (2017)

Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes
por: Kiss, Katalin, et al.
Publicado: (2012)

Acylacetylenes in multiple functionalization of hydroxyquinolines and quinolones
por: Belyaeva, Kseniya V., et al.
Publicado: (2020)

N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives
por: Orsy, György, et al.
Publicado: (2020)

Ortho‐Quinone Methide Driven Synthesis of New O,N‐ or N,N‐Heterocycles
por: Szatmári, István, et al.
Publicado: (2019)

Stereoselective Synthesis and Cytoselective Toxicity of Monoterpene-Fused 2-Imino-1,3-thiazines
por: Szakonyi, Zsolt, et al.
Publicado: (2014)

Selective Fluorescent Probes for High-Throughput Functional Diagnostics of the Human Multidrug Transporter P-Glycoprotein (ABCB1)
por: Szabó, Edit, et al.
Publicado: (2022)

8‐Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
por: Odingo, Joshua O., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0f1p2q55g7sg71o374jvha2a8k