Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models

BACKGROUND: Genetic variants and mutations in triggering receptor expressed in myeloid cells (TREM2) are associated with premature and late onset Alzheimer’s disease (AD). METHODS: We developed a panel of monoclonal antibodies, the selected lead of which was avidly shown to bind the extracellular do...

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Detalles Bibliográficos
Autores principales: Fassler, Michael, Rappaport, Maya Saban, Cuño, Clara Benaim, George, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796541/
https://www.ncbi.nlm.nih.gov/pubmed/33422057
http://dx.doi.org/10.1186/s12974-020-01980-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796541/
https://www.ncbi.nlm.nih.gov/pubmed/33422057
http://dx.doi.org/10.1186/s12974-020-01980-5

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