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Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models
BACKGROUND: Genetic variants and mutations in triggering receptor expressed in myeloid cells (TREM2) are associated with premature and late onset Alzheimer’s disease (AD). METHODS: We developed a panel of monoclonal antibodies, the selected lead of which was avidly shown to bind the extracellular do...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796541/ https://www.ncbi.nlm.nih.gov/pubmed/33422057 http://dx.doi.org/10.1186/s12974-020-01980-5 |