Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity

BACKGROUND: Tumor-targeted nanoparticles hold great promise as new tools for therapy of liquid cancers. Furthermore, the therapeutic efficacy of nanoparticles can be improved by enhancing the cancer cellular internalization. METHODS: In this study, we developed a humanized bispecific antibody (BsAbs...

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Detalles Bibliográficos
Autores principales: Ho, Kai-Wen, Chen, I.-J.u, Cheng, Yi-An, Liao, Tzu-Yi, Liu, En-Shuo, Chen, Huei-Jen, Lu, Yun-Chi, Su, Yu-Cheng, Roffler, Steve R., Huang, Bo-Cheng, Liu, Hui-Ju, Huang, Ming-Yii, Chen, Chiao-Yun, Cheng, Tian-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796588/
https://www.ncbi.nlm.nih.gov/pubmed/33422061
http://dx.doi.org/10.1186/s12951-020-00752-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796588/
https://www.ncbi.nlm.nih.gov/pubmed/33422061
http://dx.doi.org/10.1186/s12951-020-00752-w

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