Cargando…

Genetic screening for single-cell variability modulators driving therapy resistance

Cellular plasticity describes cells’ ability to transition from one set of phenotypes to another. In melanoma, transient fluctuations in the molecular state of tumor cells mark the formation of rare cells primed to survive BRAF inhibition and reprogram into a stably drug resistant fate. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torre, Eduardo A., Arai, Eri, Bayatpour, Sareh, Jiang, Connie L., Beck, Lauren E., Emert, Benjamin L., Shaffer, Sydney M., Mellis, Ian A., Fane, Mitchell E., Alicea, Gretchen M., Budinich, Krista A., Weeraratna, Ashani T., Shi, Junwei, Raj, Arjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796998/ https://www.ncbi.nlm.nih.gov/pubmed/33398196 http://dx.doi.org/10.1038/s41588-020-00749-z

Ejemplares similares

Disrupting cellular memory to overcome drug resistance
por: Harmange, Guillaume, et al.
Publicado: (2023)

ClampFISH detects individual nucleic-acid molecules using click chemistry based amplification
por: Rouhanifard, Sara H., et al.
Publicado: (2018)

Variability within rare cell states enables multiple paths towards drug resistance
por: Emert, Benjamin L., et al.
Publicado: (2021)

A glitch in the matrix: Age-dependent changes in the extracellular matrix facilitate common sites of metastasis
por: Marino, Gloria E., et al.
Publicado: (2020)

Autophagy- An emerging target for melanoma therapy
por: Ndoye, Abibatou, et al.
Publicado: (2016)

Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells
por: Jain, Naveen, et al.
Publicado: (2023)

Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells
por: Jiang, Connie L., et al.
Publicado: (2022)

In the Wnt-er of life: Wnt signalling in melanoma and ageing
por: Kaur, Amanpreet, et al.
Publicado: (2016)

Completing the Great Unfinished Symphony of Cancer Together: The Importance of Immigrants in Cancer Research
por: Morin, Pat J., et al.
Publicado: (2020)

Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another?
por: Mellis, Ian A., et al.
Publicado: (2015)

Gene Expression Profiling: From Microarrays to Medicine
por: Weeraratna, Ashani T., et al.
Publicado: (2004)

A Series of BRAF- and NRAS-Driven Murine Melanoma Cell Lines with Inducible Gene Modulation Capabilities
por: Bok, Ilah, et al.
Publicado: (2021)

Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals
por: Sanford, Eric M, et al.
Publicado: (2020)

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
por: Shaffer, Sydney M., et al.
Publicado: (2017)

Visualizing adenosine to inosine RNA editing in single mammalian cells
por: Mellis, Ian A., et al.
Publicado: (2017)

Turbo FISH: A Method for Rapid Single Molecule RNA FISH
por: Shaffer, Sydney M., et al.
Publicado: (2013)

Gene expression distribution deconvolution in single-cell RNA sequencing
por: Wang, Jingshu, et al.
Publicado: (2018)

SAVER: Gene expression recovery for single-cell RNA sequencing
por: Huang, Mo, et al.
Publicado: (2018)

Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels
por: Dar, Roy D., et al.
Publicado: (2016)

Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
por: Dawson, Harry D, et al.
Publicado: (2006)

Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
por: Lustig, Ana, et al.
Publicado: (2009)

Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes
por: de Mello Coelho, Valeria, et al.
Publicado: (2009)

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening
por: Gier, Rodrigo A., et al.
Publicado: (2020)

Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia
por: Gonskikh, Yulia, et al.
Publicado: (2023)

PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells
por: French, Amanda D., et al.
Publicado: (2009)

Clonal dominance of CD133(+) subset population as risk factor in tumor progression and disease recurrence of human cutaneous melanoma
por: SHARMA, BHUVNESH K., et al.
Publicado: (2012)

Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization
por: Acheampong, Kofi K., et al.
Publicado: (2021)

Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages
por: Acheampong, Kofi K., et al.
Publicado: (2022)

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting
por: Symmons, Orsolya, et al.
Publicado: (2019)

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas
por: Rebecca, Vito W., et al.
Publicado: (2023)

UV-induced Wnt7a in the human skin microenvironment specifies the fate of neural crest -like cells via suppression of Notch
por: Fukunaga-Kalabis, Mizuho, et al.
Publicado: (2015)

ClonoCluster: A method for using clonal origin to inform transcriptome clustering
por: Richman, Lee P., et al.
Publicado: (2023)

HSP70 Inhibition Blocks Adaptive Resistance and Synergizes with MEK Inhibition for the Treatment of NRAS-Mutant Melanoma
por: Parris, Joshua L.D., et al.
Publicado: (2021)

The possible role of symmetry in physics and cosmology: a contribution to platonism
por: Budinich, P
Publicado: (1995)

Conformally compactified homogeneous spaces: possible observable consequences
por: Budinich, P
Publicado: (1995)

Geometrical aspects of quantum mechanics in compactified momentum space
por: Budinich, P
Publicado: (1996)

Spinorial genesis of quantum mechanics in compactified momentum space
por: Budinich, P
Publicado: (1997)

L'arcipelago delle meraviglie: avventure di mare e di scienza
por: Budinich, Paolo
Publicado: (2000)

The Orphan Tyrosine Kinase Receptor, ROR2, Mediates Wnt5A Signaling in Metastatic Melanoma
por: O’Connell, Michael P., et al.
Publicado: (2009)

AutoCAD 2014 for dummies
por: Fane, Bill
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6fplsqbkdmpnomb7oa5u5atg5o