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G-Quadruplex loops regulate PARP-1 enzymatic activation

G-Quadruplexes are non-B form DNA structures present at regulatory regions in the genome, such as promoters of proto-oncogenes and telomeres. The prominence in such sites suggests G-quadruplexes serve an important regulatory role in the cell. Indeed, oxidized G-quadruplexes found at regulatory sites...

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Detalles Bibliográficos
Autores principales: Edwards, Andrea D, Marecki, John C, Byrd, Alicia K, Gao, Jun, Raney, Kevin D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797039/
https://www.ncbi.nlm.nih.gov/pubmed/33313902
http://dx.doi.org/10.1093/nar/gkaa1172