Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles

8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway. In this work, we studied coordinated BER of 8-oxodGuo by hOGG1 and APE1 in nucleosome core particles and found that histones transi...

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Detalles Bibliográficos
Autores principales: Ren, Mengtian, Shang, Mengdi, Wang, Huawei, Xi, Zhen, Zhou, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797075/
https://www.ncbi.nlm.nih.gov/pubmed/33290564
http://dx.doi.org/10.1093/nar/gkaa1153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797075/
https://www.ncbi.nlm.nih.gov/pubmed/33290564
http://dx.doi.org/10.1093/nar/gkaa1153

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