Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease

BACKGROUND: Both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of Alzheimer’s disease (AD). The common denominator linking the two is the catabolism of the essential amino acid, tryptophan. Metabolism via tryptophan hydroxylase results in ser...

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Detalles Bibliográficos
Autores principales: Whiley, Luke, Chappell, Katie E., D’Hondt, Ellie, Lewis, Matthew R., Jiménez, Beatriz, Snowden, Stuart G., Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Swann, Jonathan R., Hye, Abdul, Lovestone, Simon, Legido-Quigley, Cristina, Holmes, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797094/
https://www.ncbi.nlm.nih.gov/pubmed/33422142
http://dx.doi.org/10.1186/s13195-020-00741-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797094/
https://www.ncbi.nlm.nih.gov/pubmed/33422142
http://dx.doi.org/10.1186/s13195-020-00741-z

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