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Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease
BACKGROUND: Both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of Alzheimer’s disease (AD). The common denominator linking the two is the catabolism of the essential amino acid, tryptophan. Metabolism via tryptophan hydroxylase results in ser...
Autores principales: | Whiley, Luke, Chappell, Katie E., D’Hondt, Ellie, Lewis, Matthew R., Jiménez, Beatriz, Snowden, Stuart G., Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Swann, Jonathan R., Hye, Abdul, Lovestone, Simon, Legido-Quigley, Cristina, Holmes, Elaine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797094/ https://www.ncbi.nlm.nih.gov/pubmed/33422142 http://dx.doi.org/10.1186/s13195-020-00741-z |
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