Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells

As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. However, how mitochondria alteration and glucose defect contribute to pathogenesis of Alzheimer...

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Detalles Bibliográficos
Autores principales: Park, So Jung, Bae, Ji-Eun, Jo, Doo Sin, Kim, Joon Bum, Park, Na Yeon, Fang, Jianguo, Jung, Yong-Keun, Jo, Dong Gyu, Cho, Dong-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797154/
https://www.ncbi.nlm.nih.gov/pubmed/33422108
http://dx.doi.org/10.1186/s13041-020-00727-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797154/
https://www.ncbi.nlm.nih.gov/pubmed/33422108
http://dx.doi.org/10.1186/s13041-020-00727-w

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