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A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797620/ https://www.ncbi.nlm.nih.gov/pubmed/30867322 http://dx.doi.org/10.1126/scitranslmed.aau6267 |
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| author | Verma, Malvika Vishwanath, Karan Eweje, Feyisope Roxhed, Niclas Grant, Tyler Castaneda, Macy Steiger, Christoph Mazdiyasni, Hormoz Bensel, Taylor Minahan, Daniel Soares, Vance Salama, John A. F. Lopes, Aaron Hess, Kaitlyn Cleveland, Cody Fulop, Daniel J. Hayward, Alison Collins, Joy Tamang, Siddartha M. Hua, Tiffany Ikeanyi, Chinonyelum Zeidman, Gal Mule, Elizabeth Boominathan, Sooraj Popova, Ellena Miller, Jonathan B. Bellinger, Andrew M. Collins, David Leibowitz, Dalia Batra, Shelly Ahuja, Sandeep Bajiya, Manju Batra, Sonali Sarin, Rohit Agarwal, Upasna Khaparde, Sunil D. Gupta, Neeraj K. Gupta, Deepak Bhatnagar, Anuj K. Chopra, Kamal K. Sharma, Nandini Khanna, Ashwani Chowdhury, Jayeeta Stoner, Robert Slocum, Alexander H. Cima, Michael J. Furin, Jennifer Langer, Robert Traverso, Giovanni |
| author_facet | Verma, Malvika Vishwanath, Karan Eweje, Feyisope Roxhed, Niclas Grant, Tyler Castaneda, Macy Steiger, Christoph Mazdiyasni, Hormoz Bensel, Taylor Minahan, Daniel Soares, Vance Salama, John A. F. Lopes, Aaron Hess, Kaitlyn Cleveland, Cody Fulop, Daniel J. Hayward, Alison Collins, Joy Tamang, Siddartha M. Hua, Tiffany Ikeanyi, Chinonyelum Zeidman, Gal Mule, Elizabeth Boominathan, Sooraj Popova, Ellena Miller, Jonathan B. Bellinger, Andrew M. Collins, David Leibowitz, Dalia Batra, Shelly Ahuja, Sandeep Bajiya, Manju Batra, Sonali Sarin, Rohit Agarwal, Upasna Khaparde, Sunil D. Gupta, Neeraj K. Gupta, Deepak Bhatnagar, Anuj K. Chopra, Kamal K. Sharma, Nandini Khanna, Ashwani Chowdhury, Jayeeta Stoner, Robert Slocum, Alexander H. Cima, Michael J. Furin, Jennifer Langer, Robert Traverso, Giovanni |
| author_sort | Verma, Malvika |
| collection | PubMed |
| description | Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication. |
| format | Online Article Text |
| id | pubmed-7797620 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77976202021-02-12 A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment Verma, Malvika Vishwanath, Karan Eweje, Feyisope Roxhed, Niclas Grant, Tyler Castaneda, Macy Steiger, Christoph Mazdiyasni, Hormoz Bensel, Taylor Minahan, Daniel Soares, Vance Salama, John A. F. Lopes, Aaron Hess, Kaitlyn Cleveland, Cody Fulop, Daniel J. Hayward, Alison Collins, Joy Tamang, Siddartha M. Hua, Tiffany Ikeanyi, Chinonyelum Zeidman, Gal Mule, Elizabeth Boominathan, Sooraj Popova, Ellena Miller, Jonathan B. Bellinger, Andrew M. Collins, David Leibowitz, Dalia Batra, Shelly Ahuja, Sandeep Bajiya, Manju Batra, Sonali Sarin, Rohit Agarwal, Upasna Khaparde, Sunil D. Gupta, Neeraj K. Gupta, Deepak Bhatnagar, Anuj K. Chopra, Kamal K. Sharma, Nandini Khanna, Ashwani Chowdhury, Jayeeta Stoner, Robert Slocum, Alexander H. Cima, Michael J. Furin, Jennifer Langer, Robert Traverso, Giovanni Sci Transl Med Report Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication. American Association for the Advancement of Science 2019-03-13 2019 /pmc/articles/PMC7797620/ /pubmed/30867322 http://dx.doi.org/10.1126/scitranslmed.aau6267 Text en © 2019 The Authors, some rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Report Verma, Malvika Vishwanath, Karan Eweje, Feyisope Roxhed, Niclas Grant, Tyler Castaneda, Macy Steiger, Christoph Mazdiyasni, Hormoz Bensel, Taylor Minahan, Daniel Soares, Vance Salama, John A. F. Lopes, Aaron Hess, Kaitlyn Cleveland, Cody Fulop, Daniel J. Hayward, Alison Collins, Joy Tamang, Siddartha M. Hua, Tiffany Ikeanyi, Chinonyelum Zeidman, Gal Mule, Elizabeth Boominathan, Sooraj Popova, Ellena Miller, Jonathan B. Bellinger, Andrew M. Collins, David Leibowitz, Dalia Batra, Shelly Ahuja, Sandeep Bajiya, Manju Batra, Sonali Sarin, Rohit Agarwal, Upasna Khaparde, Sunil D. Gupta, Neeraj K. Gupta, Deepak Bhatnagar, Anuj K. Chopra, Kamal K. Sharma, Nandini Khanna, Ashwani Chowdhury, Jayeeta Stoner, Robert Slocum, Alexander H. Cima, Michael J. Furin, Jennifer Langer, Robert Traverso, Giovanni A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title | A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title_full | A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title_fullStr | A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title_full_unstemmed | A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title_short | A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| title_sort | gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment |
| topic | Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797620/ https://www.ncbi.nlm.nih.gov/pubmed/30867322 http://dx.doi.org/10.1126/scitranslmed.aau6267 |
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