Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates

Adeno-Associated Virus (AAV)-based gene therapy vectors are in development for many inherited human disorders. In nonclinical studies, cellular immune responses mediated by cytotoxic T cells may target vector-transduced cells, which could impact safety and efficacy. Here, we describe the bioanalytic...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Patton, Kathryn, Kasprzyk, Theresa, Long, Brian, Gupta, Soumi, Zoog, Stephen J., Tracy, Kristin, Vettermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797710/
https://www.ncbi.nlm.nih.gov/pubmed/33432123
http://dx.doi.org/10.1038/s41434-020-00214-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797710/
https://www.ncbi.nlm.nih.gov/pubmed/33432123
http://dx.doi.org/10.1038/s41434-020-00214-w

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