Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus

We report herein the synthesis and evaluation of phenyl ureas derived from 4-oxotetrahydropyrimidine as novel capsid assembly modulators of hepatitis B virus (HBV). Among the derivatives, compound 27 (58031) and several analogs showed an activity of submicromolar EC(50) against HBV and low cytotoxic...

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Detalles Bibliográficos
Autores principales: Hwang, Nicky, Ban, Haiqun, Chen, Junjun, Ma, Julia, Liu, Hui, Lam, Patrick, Kulp, John, Menne, Stephan, Chang, Jinhong, Guo, Ju-Tao, Du, Yanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797712/
https://www.ncbi.nlm.nih.gov/pubmed/33456291
http://dx.doi.org/10.1007/s00044-020-02677-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797712/
https://www.ncbi.nlm.nih.gov/pubmed/33456291
http://dx.doi.org/10.1007/s00044-020-02677-3

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