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Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
Solid tumors often grow in a micro-environment characterized by < 2% O(2) tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the hypoxia-inducible factor-1α (HIF-1α), a transcription factor that controls up to 200 ge...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798239/ https://www.ncbi.nlm.nih.gov/pubmed/33423689 http://dx.doi.org/10.1186/s13046-020-01824-3 |