PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors

BACKGROUND: Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpressed oncogene that is associated with AR in LNCaP prostate cancer cells, and...

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Detalles Bibliográficos
Autores principales: Videira, Alexandre, Beckedorff, Felipe C., daSilva, Lucas F., Verjovski-Almeida, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798249/
https://www.ncbi.nlm.nih.gov/pubmed/33430890
http://dx.doi.org/10.1186/s12964-020-00691-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798249/
https://www.ncbi.nlm.nih.gov/pubmed/33430890
http://dx.doi.org/10.1186/s12964-020-00691-x

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