The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9

Imbalance of macrophage polarization plays an indispensable role in acute lung injury (ALI), which is considered as a promising target. Matrix metalloproteinase-9 (MMP-9) is expressed in the macrophage, and has a pivotal role in secreting inflammatory cytokines. We reported that saquinavir (SQV), a...

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Detalles Bibliográficos
Autores principales: Tong, Yao, Yu, Zhuang, Chen, Zhixia, Zhang, Renlingzi, Ding, Xibing, Yang, Xiaohu, Niu, Xiaoyin, Li, Mengzhu, Zhang, Lingling, Billiar, Timothy R., Pitt, Bruce R., Li, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798387/
https://www.ncbi.nlm.nih.gov/pubmed/33431821
http://dx.doi.org/10.1038/s41419-020-03320-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798387/
https://www.ncbi.nlm.nih.gov/pubmed/33431821
http://dx.doi.org/10.1038/s41419-020-03320-0

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