Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids

Duplication or deficiency of the X‐linked MECP2 gene reliably produces profound neurodevelopmental impairment. MECP2 mutations are almost universally responsible for Rett syndrome (RTT), and particular mutations and cellular mosaicism of MECP2 may underlie the spectrum of RTT symptomatic severity. N...

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Detalles Bibliográficos
Autores principales: Trujillo, Cleber A, Adams, Jason W, Negraes, Priscilla D, Carromeu, Cassiano, Tejwani, Leon, Acab, Allan, Tsuda, Ben, Thomas, Charles A, Sodhi, Neha, Fichter, Katherine M, Romero, Sarah, Zanella, Fabian, Sejnowski, Terrence J, Ulrich, Henning, Muotri, Alysson R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799367/
https://www.ncbi.nlm.nih.gov/pubmed/33501759
http://dx.doi.org/10.15252/emmm.202012523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799367/
https://www.ncbi.nlm.nih.gov/pubmed/33501759
http://dx.doi.org/10.15252/emmm.202012523

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