Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction

OBJECTIVE: Cartilage health is maintained in response to a range of mechanical stimuli including compressive, shear and tensile strains and associated alterations in osmolality. The osmotic-sensitive ion channel Transient Receptor Potential Vanilloid 4 (TRPV4) is required for mechanotransduction. Me...

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Detalles Bibliográficos
Autores principales: Fu, S., Meng, H., Inamdar, S., Das, B., Gupta, H., Wang, W., Thompson, C.L., Knight, M.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799379/
https://www.ncbi.nlm.nih.gov/pubmed/33395574
http://dx.doi.org/10.1016/j.joca.2020.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799379/
https://www.ncbi.nlm.nih.gov/pubmed/33395574
http://dx.doi.org/10.1016/j.joca.2020.08.002

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