Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity

BACKGROUND: Doxorubicin (DOX) induces cardiotoxicity in part by activation of matrix metalloproteinases (MMPs). Sacubitril/valsartan (Sac/Val) exerts additive cardioprotective actions over renin-angiotensin-aldosterone inhibitors in preclinical models of myocardial infarction and in heart failure pa...

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Detalles Bibliográficos
Autores principales: Boutagy, Nabil E., Feher, Attila, Pfau, Daniel, Liu, Zhao, Guerrera, Nicole M., Freeburg, Lisa A., Womack, Sydney J., Hoenes, Abigail C., Zeiss, Caroline, Young, Lawrence H., Spinale, Francis G., Sinusas, Albert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799406/
https://www.ncbi.nlm.nih.gov/pubmed/33437965
http://dx.doi.org/10.1016/j.jaccao.2020.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799406/
https://www.ncbi.nlm.nih.gov/pubmed/33437965
http://dx.doi.org/10.1016/j.jaccao.2020.09.007

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