Cargando…

Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin

PURPOSE: The aim was to explore the correlation between increasing doses of [6R]-5,10-methylenetetrahydrofolate (arfolitixorin) and plasma concentrations of deoxyuridine (dUr) in patients with metastatic colorectal cancer (mCRC), subjected to 5-fluorouracil (5-FU)-based chemotherapy. The aim was fur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taflin, Helena, Odin, Elisabeth, Carlsson, Göran, Tell, Roger, Gustavsson, Bengt, Wettergren, Yvonne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801297/ https://www.ncbi.nlm.nih.gov/pubmed/33099678 http://dx.doi.org/10.1007/s00280-020-04173-2

Ejemplares similares

Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer
por: Taflin, Helena, et al.
Publicado: (2018)

Increasing Dosage of Leucovorin Results in Pharmacokinetic and Gene Expression Differences When Administered as Two-Hour Infusion or Bolus Injection to Patients with Colon Cancer
por: Taflin, Helena, et al.
Publicado: (2022)

Pharmacokinetics of preoperative intraperitoneal 5-FU in patients with pancreatic ductal adenocarcinoma
por: Öman, Mikael, et al.
Publicado: (2021)

Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer
por: Taflin, Helena, et al.
Publicado: (2014)

A phase I/II study of arfolitixorin and 5-fluorouracil in combination with oxaliplatin (plus or minus bevacizumab) or irinotecan in metastatic colorectal cancer
por: Carlsson, G., et al.
Publicado: (2022)

Folate levels measured by LC–MS/MS in patients with colorectal cancer treated with different leucovorin dosages
por: Taflin, Helena, et al.
Publicado: (2014)

A pharmacokinetic and pharmacodynamic investigation of Modufolin(®) compared to Isovorin(®) after single dose intravenous administration to patients with colon cancer: a randomized study
por: Wettergren, Yvonne, et al.
Publicado: (2014)

Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer
por: Lindskog, Elinor B., et al.
Publicado: (2012)

Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival
por: Salimzadeh, Hamideh, et al.
Publicado: (2020)

Thymidine phosphorylase expression is associated with time to progression in patients with metastatic colorectal cancer
por: Lindskog, Elinor Bexe, et al.
Publicado: (2014)

Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer
por: Gustavsson, Bengt, et al.
Publicado: (2015)

Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B(12) supplementation
por: Stoffregen, Clemens C., et al.
Publicado: (2016)

Prolonged postoperative length of stay may be a valuable marker for susceptibility to relapse beyond established risk factors in patients with stage III colon cancer
por: Emland, Frans, et al.
Publicado: (2022)

5-FU toxicity and nutritional deficiencies.
por: Stenram, U.
Publicado: (1993)

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine
por: Rusling, David A., et al.
Publicado: (2009)

Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates
por: Liu, Erkai, et al.
Publicado: (2015)

3′-O-Acetyl-2′-deoxyuridine
por: Doboszewski, Bogdan, et al.
Publicado: (2010)

5-Bromo-2’-deoxyuridine labeling: historical perspectives, factors influencing the detection, toxicity, and its implications in the neurogenesis
por: Martí-Clúa, Joaquín
Publicado: (2023)

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus
por: Li, Ke, et al.
Publicado: (2011)

Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase
por: Homma, Kohei, et al.
Publicado: (2009)

A Deoxyuridine-Based Far-Red Emitting Viscosity Sensor
por: Wang, Mengyuan, et al.
Publicado: (2016)

Synthesis and Photophysical Study of 2′-Deoxyuridines Labeled with Fluorene Derivatives
por: Cho, Hyun Yi, et al.
Publicado: (2012)

Enzyme kinetics of deoxyuridine triphosphatase from Western corn rootworm
por: Riera-Ruiz, Carlos, et al.
Publicado: (2023)

5-FU-induced cardiac toxicity - an underestimated problem in radiooncology?
por: Steger, Felix, et al.
Publicado: (2012)

Intratumoral regulatory T cells from colon cancer patients comprise several activated effector populations
por: Szeponik, Louis, et al.
Publicado: (2021)

Diesterified Derivatives of 5-Iodo-2′-Deoxyuridine as Cerebral Tumor Tracers
por: Rösler, Thomas W., et al.
Publicado: (2014)

Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
por: Matsumoto, Yoshihiro, et al.
Publicado: (2015)

NMR and UV Studies of 4-Thio-2′-deoxyuridine and Its Derivatives
por: Zhang, Xiaohui, et al.
Publicado: (2011)

Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
por: Webley, S D, et al.
Publicado: (2001)

Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2′-deoxyuridine
por: Hua, Hui, et al.
Publicado: (2011)

Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2′-deoxyuridine
por: Bijnsdorp, Irene V., et al.
Publicado: (2009)

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine
por: Gayakhe, Vijay, et al.
Publicado: (2017)

Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
por: Brickell, K, et al.
Publicado: (2003)

Biological toxicities as surrogate markers of efficacy in patients treated with mTOR inhibitors for metastatic renal cell carcinoma
por: Jebali, M., et al.
Publicado: (2017)

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs
por: Miura, Koh, et al.
Publicado: (2010)

Purification, crystallization and preliminary crystallographic analysis of deoxyuridine triphosphate nucleotidohydrolase from Arabidopsis thaliana
por: Bajaj, Mamta, et al.
Publicado: (2007)

In vivo uptake of 131I-5-iodo-2-deoxyuridine by malignant tumours in man.
por: Philip, P. A., et al.
Publicado: (1991)

Simultaneous Detection of FISH Signals and Bromo-Deoxyuridine Incorporation in Fixed Tissue Cultured Cells
por: Moralli, Daniela, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ur596tpp95okjpljbr0ofgs9v0