Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy

Plasminogen activator inhibitor-1 (PAI-1) has a cardioprotective function in mice by repressing cardiac fibrosis through TGF-β and plasminogen-mediated pathways. In addition it is known to be involved in the recruitment and polarization of monocytes/macrophages towards a M2 phenotype in cancer. Here...

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Detalles Bibliográficos
Autores principales: Baumeier, Christian, Escher, Felicitas, Aleshcheva, Ganna, Pietsch, Heiko, Schultheiss, Heinz-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801308/
https://www.ncbi.nlm.nih.gov/pubmed/33432417
http://dx.doi.org/10.1007/s00395-020-00840-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801308/
https://www.ncbi.nlm.nih.gov/pubmed/33432417
http://dx.doi.org/10.1007/s00395-020-00840-w

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