HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN

The nucleolus is a nuclear structure composed of ribosomal DNA (rDNA), and functions as a site for rRNA synthesis and processing. The rDNA is guanine-rich and prone to form G-quadruplex (G4), a secondary structure of DNA. We have recently found that HERC2, an HECT ubiquitin ligase, promotes BLM and...

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Detalles Bibliográficos
Autores principales: Zhu, Mingzhang, Wu, Wenwen, Togashi, Yukiko, Liang, Weixin, Miyoshi, Yasuo, Ohta, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801386/
https://www.ncbi.nlm.nih.gov/pubmed/33432007
http://dx.doi.org/10.1038/s41598-020-79715-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801386/
https://www.ncbi.nlm.nih.gov/pubmed/33432007
http://dx.doi.org/10.1038/s41598-020-79715-y

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