Stabilizing the closed SARS-CoV-2 spike trimer

The trimeric spike (S) protein of SARS-CoV-2 is the primary focus of most vaccine design and development efforts. Due to intrinsic instability typical of class I fusion proteins, S tends to prematurely refold to the post-fusion conformation, compromising immunogenic properties and prefusion trimer y...

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Detalles Bibliográficos
Autores principales: Juraszek, Jarek, Rutten, Lucy, Blokland, Sven, Bouchier, Pascale, Voorzaat, Richard, Ritschel, Tina, Bakkers, Mark J. G., Renault, Ludovic L. R., Langedijk, Johannes P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801441/
https://www.ncbi.nlm.nih.gov/pubmed/33431842
http://dx.doi.org/10.1038/s41467-020-20321-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801441/
https://www.ncbi.nlm.nih.gov/pubmed/33431842
http://dx.doi.org/10.1038/s41467-020-20321-x

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