Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation

Gonadotoxic chemotherapeutics, such as cyclophosphamide, can cause early menopause and infertility in women. Earlier histological studies showed ovarian reserve depletion via severe DNA damage and apoptosis, but others suggested activation of PI3K/PTEN/Akt pathway and follicle ‘burn-out’ as a cause....

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Detalles Bibliográficos
Autores principales: Titus, S., Szymanska, K. J., Musul, B., Turan, V., Taylan, E., Garcia- Milian, R., Mehta, S., Oktay, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801500/
https://www.ncbi.nlm.nih.gov/pubmed/33431979
http://dx.doi.org/10.1038/s41598-020-79643-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801500/
https://www.ncbi.nlm.nih.gov/pubmed/33431979
http://dx.doi.org/10.1038/s41598-020-79643-x

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