Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors

Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors of hNE. Biological scre...

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Detalles Bibliográficos
Autores principales: Xu, Yanzhao, Qi, Na, Wen, Hui, Zhang, Gang, Wang, Yuchen, Cui, Huaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801566/
https://www.ncbi.nlm.nih.gov/pubmed/33456292
http://dx.doi.org/10.1007/s00044-020-02684-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801566/
https://www.ncbi.nlm.nih.gov/pubmed/33456292
http://dx.doi.org/10.1007/s00044-020-02684-4

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