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Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes

BACKGROUND: The vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genome-wide accessibility of histone protein surfaces within nucleosomes by assessin...

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Detalles Bibliográficos
Autores principales: Marr, Luke T., Ocampo, Josefina, Clark, David J., Hayes, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802155/
https://www.ncbi.nlm.nih.gov/pubmed/33430969
http://dx.doi.org/10.1186/s13072-020-00381-5