The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

BACKGROUND: The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the chemokine CXCL12. CXCL12 regulates the homing to the BM niche by mediating the transendothelial migration and adhesion/retention of the...

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Detalles Bibliográficos
Autores principales: Ren, Zemin, Lantermans, Hildo, Kuil, Annemieke, Kraan, Willem, Arenzana-Seisdedos, Fernando, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802348/
https://www.ncbi.nlm.nih.gov/pubmed/33436043
http://dx.doi.org/10.1186/s13045-021-01031-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802348/
https://www.ncbi.nlm.nih.gov/pubmed/33436043
http://dx.doi.org/10.1186/s13045-021-01031-3

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