The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation

Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis. However, cycloheximide is also known to activate p38 mitogen-activated protein kinase (MAPK), which can delay mitotic entry through a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lockhead, Sarah, Moskaleva, Alisa, Kamenz, Julia, Chen, Yuxin, Kang, Minjung, Reddy, Anay R., Santos, Silvia D.M., Ferrell, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802425/
https://www.ncbi.nlm.nih.gov/pubmed/32668239
http://dx.doi.org/10.1016/j.celrep.2020.107901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802425/
https://www.ncbi.nlm.nih.gov/pubmed/32668239
http://dx.doi.org/10.1016/j.celrep.2020.107901

Ejemplares similares